HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Hydroxyazetidine hydrochloride → 1-((3-Fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)methyl)azetidin-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Hydroxyazetidine hydrochloride | HCID 2759290 | — |
| Reactant | 3-Fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzaldehyde | HCID 59174907 | — |
| Product | 1-((3-Fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)methyl)azetidin-3-ol | HCID 44601443 | — |
Reaction Steps
Synthesized from 3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-yl)benzaldehyde (0.500 g, 1.34 mmol) and 3-hydroxyazetidine hydrochloride (0.293 g, 2.67 mmol) according to the general procedure for reductive amination to afford 1-((3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-yl)phenyl)methyl)azetidin-3-ol as a pale yellow solid. MS (ESI) m/z: Calculated: 431.2; Observed: 432.1 (M++1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07842685B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-ca2d67bd6e0b42e595ae378f92830fbc |
| Source note | uspto-grants-2010_11 |