Dichloromethane → HCID 68635025, compound

Participants

Reaction Steps

Dess-Martin periodinane (0.524 g, 1.24 mmol) was added to a solution of 1-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)propan-1-ol (0.500 g, 1.24 mmol) in dichloromethane (25.00 ml, 1.24 mmol), and the reaction was stirred at ambient temperature for 60 min. Saturated aq. NaHCO3 was added and the reaction stirred for 5 min. The organic layer was dried, filtered, and concentrated in vacuo and the residue purified by silica gel chromatography: ISCO 120 g column, 20-30% (3% Et3N in EtOAc)/Hex to give 1-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)propan-1-one. MS (ESI) m/z: Calculated: 402.1; Observed: 403.0 (M++H).

Provenance & Evidence