Potassium Hydroxide → HCID 44599524, compound

Participants

Reaction Steps

Ethyl 2-(2-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)ethylamino)-2-oxoacetate (100 mg, 0.20 mmol) was dissolved in ethanol (2.0 mL) before crushed potassium hydroxide (23 mg, 0.41 mmol) was added and stirred at ambient temperature for 30 min. The reaction mixture was concentrated, suspended in water, acidified with 2 N HCl, filtered, and washed with water. The title compound was obtained after purification via preparatory LC. MS (ESI) m/z: Calculated: 461.1; Observed: 462.0 (M++H).

Provenance & Evidence