HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Cyanobenzaldehyde → 4-(5-(1-Phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Cyanobenzaldehyde | HCID 66042 | — |
| Reactant | 3-Aminopyridine-2-thiol | HCID 5463181 | — |
| Reactant | 3-amino-6-(1-phenylcyclopropyl)pyridine-2(1H)-thione | HCID 59174836 | — |
| Product | 4-(5-(1-Phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzonitrile | HCID 67112922 | — |
Reaction Steps
Reaction of 3-amino-6-(1-phenylcyclopropyl)pyridine-2(1H)-thione (55.6 mg, 229 μmol) and 4-formylbenzonitrile (29 mg, 218 μmol) according to Reference U and the general procedure for oxidative condensation of 3-aminopyridine-2-thione with aryl aldehydes gave 4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzonitrile as a light yellow solid. MS (ESI) m/z: Calculated: 353.1; Observed: 354.1 (M++1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07842685B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-4bf1319764b04bccba913de11dc0df26 |
| Source note | uspto-grants-2010_11 |