HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl alaninate hydrochloride → HCID 67111916, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl alaninate hydrochloride | HCID 11275390 | — |
| Reactant | 3-Fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzaldehyde | HCID 59174907 | — |
| Product | HCID 67111916 | HCID 67111916 | — |
Reaction Steps
Reaction of 3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzaldehyde (105.5 mg, 0.282 mmol) and L-alanine tert-butyl ester hydrochloride (51.2 mg, 0.282 mmol) according to Reference R and the general procedure for reductive amination to give (S)-tert-butyl 2-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzylamino)propanoate as a yellow-orange solid. MS (ESI) m/z: Calculated: 503.2; Observed: 503.8 (M++1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07842685B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-586a379496cb476e8e5fa555162985df |
| Source note | uspto-grants-2010_11 |