Trifluoroacetic acid → HCID 44599852, compound

Participants

Reaction Conditions

Reaction Steps

Trifluoroacetic acid (1.0 mL, 12.98 mmol) was added to a solution of (S)-tert-butyl 2-((3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)methylamino)propanoate (140.6 mg, 0.279 mmol) in DCM (2.1 mL) at 25° C., and the resulting mixture was stirred at 25° C. for 16 h. The reaction mixture was then concentrated in vacuo and the brown residue was taken up in DMSO (2.0 mL) and purified by rpHPLC (10-100% CH3CN/water+0.1% TFA) to provide (S)-2-((3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)methylamino)-propanoic acid as a light yellow solid. MS (ESI) m/z: Calculated: 447.1; Observed: 448.2 (M++1).

Provenance & Evidence