HuagongsheHuagongshe Chemistry Print Report · For research reference only
D-Alanine tert-butyl ester hydrochloride → HCID 68635402, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | D-Alanine tert-butyl ester hydrochloride | HCID 16211919 | — |
| Reactant | 3-Fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzaldehyde | HCID 59174907 | — |
| Product | HCID 68635402 | HCID 68635402 | — |
Reaction Steps
Reaction of 3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzaldehyde (101.1 mg, 0.270 mmol) and D-alanine tert-butyl ester hydrochloride (49.1 mg, 0.270 mmol) according to Reference R and the general procedure for reductive amination to give (R)-tert-butyl 2-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzylamino)propanoate as a yellow-orange solid. MS (ESI) m/z: Calculated: 503.2; Observed: 503.8 (M++1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07842685B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-4e2a827d4425458784775454fc21424b |
| Source note | uspto-grants-2010_11 |