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HRID1177579

反应详情

EQUATION

反应方程式

HRID 1177579 的结构方程式

REACTANTS

反应物

2
结构：COC(=O)C1(N)CC1.Cl
HCID12760695

Methyl 1-aminocyclopropane-1-carboxylate--hydrogen chloride (1/1)

C5H10ClNO2

结构：O=Cc1ccc(-c2nc3ccc(C4(c5ccccc5)CC4)nc3s2)c(F)c1
HCID59174907

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)C1(NCc2ccc(-c3nc4ccc(C5(c6ccccc6)CC5)nc4s3)c(F)c2)CC1
HCID67112085

未命名化合物

PROCEDURE

实验过程

Reaction of 3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzaldehyde (98.0 mg, 0.262 mmol) and methyl 1-aminocyclopropanecarboxylate hydrochloride (40 mg, 0.262 mmol) according to Reference R and the general procedure for reductive amination to give methyl 1-(3-fluoro-4-(5-(1-phenylcyclopropyl)-thiazolo[5,4-b]pyridin-2-yl)benzylamino)-cyclopropanecarboxylate as a tan solid. MS (ESI) m/z: Calculated: 473.2; Observed: 474.1 (M++1).