HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2-aminoisobutyrate hydrochloride → HCID 68636247, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2-aminoisobutyrate hydrochloride | HCID 13258034 | — |
| Reactant | 3-Fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzaldehyde | HCID 59174907 | — |
| Product | HCID 68636247 | HCID 68636247 | — |
Reaction Steps
Reaction of 3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzaldehyde (100.3 mg, 0.268 mmol) and methyl 2-amino-2-methylpropanoate hydrochloride (41 mg, 0.268 mmol) according to Reference R and the general procedure for reductive amination to give methyl 2-(3-fluoro-4-(5-(1-phenylcyclopropyl)-thiazolo[5,4-b]pyridin-2-yl)benzylamino)-2-methylpropanoate as a yellow-orange oil. MS (ESI) m/z: Calculated: 475.2; Observed: 476.1 (M++1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07842685B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-6df73e2d15a74e41844c27127f923fe7 |
| Source note | uspto-grants-2010_11 |