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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1177581Generated: November 3, 2026

2-Azetidinecarboxylic acid, (S)- → HCID 44600008, compound

https://huagongshe.com/reaction/1177581

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Azetidinecarboxylic acid, (S)-HCID 16486—
Reactant3-Fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzaldehydeHCID 59174907—
ProductHCID 44600008HCID 44600008—

Reaction Steps

Reaction of 3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzaldehyde (93.3 mg, 0.249 mmol) and L-azetidine-2-carboxylic acid (76 mg, 0.748 mμmol) according to Reference R and the general procedure for reductive amination gave (S)-1-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzyl)-azetidine-2-carboxylic acid as a light yellow solid. MS (ESI) m/z: Calculated: 459.1; Observed: 460.0 (M++1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07842685B2
Source datasetuspto-grants-2010_11
ORD IDord-31263fb2dafa48dda533a851f8eabe12
Source noteuspto-grants-2010_11