HuagongsheHuagongshe Chemistry Print Report · For research reference only
D-Azetidine-2-carboxylic acid → HCID 44600007, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | D-Azetidine-2-carboxylic acid | HCID 637601 | — |
| Reactant | 3-Fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzaldehyde | HCID 59174907 | — |
| Product | HCID 44600007 | HCID 44600007 | — |
Reaction Steps
Reaction of 3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzaldehyde (106.1 mg, 0.283 mmol) and (R)-azetidine-2-carboxylic acid (86 mg, 0.850 mmol) according to Reference R and the general procedure for reductive amination gave (R)-1-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzyl)azetidine-2-carboxylic acid as a brown solid. MS (ESI) m/z: Calculated: 459.1; Observed: 460.1 (M++1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07842685B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-46ffb42057974dc99220d6a4a68f5f26 |
| Source note | uspto-grants-2010_11 |