HuagongsheHuagongshe Chemistry Print Report · For research reference only
D-Proline → HCID 44600160, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | D-Proline | HCID 8988 | — |
| Reactant | 3-Fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzaldehyde | HCID 59174907 | — |
| Product | HCID 44600160 | HCID 44600160 | — |
Reaction Steps
Reaction of 3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzaldehyde (96.1 mg, 0.257 mmol) and D-(+)-proline (88.6 mg, 0.770 mmol) according to Reference R and the general procedure for reductive amination to give (R)-1-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzyl)pyrrolidine-2-carboxylic acid as a light yellow solid. MS (ESI) m/z: Calculated: 473.2; Observed: 474.2 (M++1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07842685B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-048d3803e6574c08b5d661c973074e89 |
| Source note | uspto-grants-2010_11 |