HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzaldehyde → HCID 44600161, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzaldehyde | HCID 59174907 | — |
| Reactant | 3-Azetidineacetic acid trifluoroacetate | HCID 67112606 | — |
| Product | HCID 44600161 | HCID 44600161 | — |
Reaction Steps
Reaction of 3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzaldehyde (100.0 mg, 0.267 mmol) and 2-(azetidin-3-yl)acetic acid trifluoroacetic acid (88.1 mg, 0.384 mmol) according to Reference R and the general procedure for reductive amination to give 2-(1-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzyl)azetidin-3-yl)acetic acid as a tan solid. MS (ESI) m/z: Calculated: 473.2; Observed: 474.1 (M++1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07842685B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-334e2cd80a9f43a8986d2f25fe7d74b5 |
| Source note | uspto-grants-2010_11 |