Methyl azetidine-3-carboxylate hydrochloride → Methyl 1-(4-(5-(1-cyclobutylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)-3-fluorobenzyl)azetidine-3-carboxylate

Participants

Reaction Steps

Reaction of 4-(5-(1-cyclobutylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)-3-fluorobenzaldehyde (66.2 mg, 0.188 mmol) and methyl azetidine-3-carboxylate hydrochloride (42.7 mg, 0.282 mmol) according to Reference R and the general procedure for reductive amination to give methyl 1-(4-(5-(1-cyclobutylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)-3-fluorobenzyl)azetidine-3-carboxylate as a white solid. MS (ESI) m/z: Calculated: 451.2; Observed: 451.9 (M++1).

Provenance & Evidence