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HRID1177600

反应详情

EQUATION

反应方程式

HRID 1177600 的结构方程式

REACTANTS

反应物

2
结构：COC(=O)C1CNC1.Cl
HCID21100040

Methyl azetidine-3-carboxylate--hydrogen chloride (1/1)

C5H10ClNO2

结构：O=Cc1ccc(-c2nc3ccc(C4(C5CC(F)(F)C5)CC4)nc3s2)c(F)c1
HCID86638727

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)C1CN(Cc2ccc(-c3nc4ccc(C5(C6CC(F)(F)C6)CC5)nc4s3)c(F)c2)C1
HCID67112099

未命名化合物

PROCEDURE

实验过程

Reaction of 4-(5-(1-(3,3-difluorocyclobutyl)cyclopropyl)thiazolo[5,4-b]pyridin-2-yl)-3-fluorobenzaldehyde (112.0 mg, 0.288 mmol) and methyl azetidine-3-carboxylate hydrochloride (65.6 mg, 0.433 mmol) according to Reference R and the general procedure for reductive amination gave methyl 1-(4-(5-(1-(3,3-difluorocyclobutyl)cyclopropyl)-thiazolo[5,4-b]pyridin-2-yl)-3-fluorobenzyl)azetidine-3-carboxylate as a white solid. MS (ESI) m/z: Calculated: 487.2; Observed: 487.8 (M++1).