Lithium Hydroxide → HCID 44600327, compound

Participants

Reaction Steps

To a solution of methyl 2-((3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)methoxy)acetate (0.040 g, 0.089 mmol) in THF (2.00 mL) was added a solution of lithium hydroxide (0.011 g, 0.45 mmol) in 1.0 mL of water. The reaction mixture was stirred for 10 min. The THF was removed, and the reaction mixture acidified to pH 1 with 5N HCl. The resulting solid was rinsed with water and diethyl ether, and the solid was dried in vacuo at 50° C. for 2 h to give 2-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzyloxy)acetic acid. MS (ESI) m/z: calculated: 434.1; Observed: 435.0 (M++1).

Provenance & Evidence