Hydrochloric Acid → HCID 44600483, compound

Participants

Reaction Steps

Hydrogen chloride 4.0 M in 1,4-dioxane (0.04 mL, 0.2 mmol) was added to a solution of (R)-N-((R)-1-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)-ethyl)-2-methylpropane-2-sulfinamide (0.0301 g, 0.06 mmol) in MeOH (5 mL). The yellow reaction mixture was allowed to stir at ambient temperature for 18 h. The crude reaction mixture was concentrated in vacuo and purified by silica gel chromatography to afford (R)-1-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)ethanamine. MS (ESI) m/z: calculated: 389.1; Observed: 390.1 (M++1).

Provenance & Evidence