Hydrochloric Acid → HCID 44600482, compound

Participants

Reaction Steps

Hydrogen chloride, 4.0 M solution in 1,4-dioxane (0.63 mL, 2.5 mmol) was added to a suspension of (R)-N-((S)-1-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)ethyl)-2-methylpropane-2-sulfinamide. (0.413 g, 0.84 mmol)) in methanol (60.00 mL). The yellow reaction mixture was allowed to stir at ambient temperature for 4 h. The crude reaction mixture was concentrated in vacuo and purified by silica gel chromatography to afford (S)-1-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)ethanamine. MS (ESI) m/z: calculated: 389.1; Observed: 390.1 (M++1).

Provenance & Evidence