Sodium t-butoxide → HCID 67111934, compound

Participants

Reaction Conditions

Reaction Steps

In a reactor tube was dissolved methyl 4-imidazolecarboxylate (0.047 g, 0.37 mmol) in ethyl alcohol (2 mL). To the solution was added sodium tert-butoxide (0.035 g, 0.37 mmol) followed by 2-(4-(bromomethyl)-2-fluorophenyl)-5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine (0.081 g, 0.18 mmol) and the reaction mixture was heated to 70° C. for 1 h. The crude reaction mixture was concentrated in vacuo and purified by silica gel chromatography to afford pure ethyl 1-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzyl)-1H-imidazole-4-carboxylate and ethyl 1-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzyl)-1H-imidazole-5-carboxylate. MS (ESI) m/z: calculated: 498.2; Observed: 499.0.

Provenance & Evidence