Lithium Hydroxide → HCID 44600485, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 1-((3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)methyl)-1H-imidazole-4-carboxylate (0.034 g, 0.068 mmol) in THF was added a solution of lithium hydroxide (0.0082 g, 0.34 mmol) in 1.0 mL of water. The reaction mixture was heated to 100° C. for 18 h. The crude reaction mixture was concentrated in vacuo. The residue was diluted with water and the pH was adjusted to 1 with aq. HCl. The solid was collected by filtration, rinsed with water and Et2O, and dried in vacuo at 50° C. for 2 h to afford 1-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzyl)-1H-imidazole-4-carboxylic acid. MS (ESI) m/z: calculated: 470.1; Observed: 471.0 (M++1).

Provenance & Evidence