2-Methylpropan-2-olate → HCID 67111849, compound

Participants

Reaction Conditions

Reaction Steps

In a sealable tube was dissolved ethyl 5H-pyrazole-3-carboxylate (0.137 g, 0.979 mmol) in ethyl alcohol (3 mL). To the solution was added tert-butoxide (0.0941 g, 0.979 mmol) followed by 2-(4-(bromomethyl)-2-fluorophenyl)-5-(1-phenylcyclopropyl)-thiazolo[5,4-b]pyridine (0.215 g, 0.489 mmol) and the reaction mixture was heated to 70° C. for 1 h. The crude reaction mixture containing an isomeric mixture was concentrated in vacuo and purified by silica gel chromatography to afford ethyl 1-(3-fluoro-4-(5-(1-phenyl-cyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzyl)-1H-pyrazole-3-carboxylate and ethyl 1-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzyl)-1H-pyrazole-5-carboxylate. MS (ESI) m/z: calculated: 498.2; Observed: 499.0 (M++1).

Provenance & Evidence