Morpholine → HCID 59174903, compound

HRID 1177621Notes

Reaction equation

HRID 1177621 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[C:11]1[S:12][C:13]2[C:18]([N:19]=1)=[CH:17][CH:16]=[C:15]([C:20]1([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH2:22][CH2:21]1)[N:14]=2)[C:5]([OH:7])=O.[NH:29]1[CH2:34][CH2:33][O:32][CH2:31][CH2:30]1>>[F:1][C:2]1[CH:3]=[C:4]([C:5]([N:29]2[CH2:34][CH2:33][O:32][CH2:31][CH2:30]2)=[O:7])[CH:8]=[CH:9][C:10]=1[C:11]1[S:12][C:13]2[C:18]([N:19]=1)=[CH:17][CH:16]=[C:15]([C:20]1([C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH2:22][CH2:21]1)[N:14]=2

Participants

3

Reactant 2

HCID 8083MorpholineHCID 573944063-Fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzoic acid

Product 1

HCID 59174903HCID 59174903, compound

Procedure

The title compound was synthesized using the described in Example 105 above using 3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzoic acid (101 mg, 0.259 mmol) and morpholine. MS (ESI) m/z: Calculated: 459.1; Observed: 460.1 (M++1).

Sources & evidence

ORD record
ord-0a0804dace5d4839846c8954259cd5b9
Source dataset
uspto-grants-2010_11
Patent number
US07842685B2

Reaction notes

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