Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1177623Generated: November 2, 2026

2-(Methylamino)ethanol → 3-fluoro-N-(2-hydroxyethyl)-N-methyl-4-(5-(1-phenylcyclopropyl)-[1,3]thiazolo[5,4-b]pyridin-2-yl)benzamide

https://huagongshe.com/reaction/1177623

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Methylamino)ethanolHCID 8016—
Reactant3-Fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzoic acidHCID 57394406—
Product3-fluoro-N-(2-hydroxyethyl)-N-methyl-4-(5-(1-phenylcyclopropyl)-[1,3]thiazolo[5,4-b]pyridin-2-yl)benzamideHCID 59174897—

Reaction Steps

The title compound was synthesized using the procedure described in Example 105 above, with 3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzoic acid (98 mg, 0.251 mmol) and 2-(methylamino)ethanol (24 μl, 0.301 mmol). MS (ESI) m/z: Calculated: 447.1; Observed: 448.1 (M++1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07842685B2
Source datasetuspto-grants-2010_11
ORD IDord-884802d1fc0d41e19c053da8fa88c306
Source noteuspto-grants-2010_11