Ethanolamine → 3-fluoro-N-(2-hydroxyethyl)-4-(5-(1-phenylcyclopropyl)[1,3]thiazolo[5,4-b]pyridin-2-yl)benzamide
Reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[C:11]1[S:12][C:13]2[C:18]([N:19]=1)=[CH:17][CH:16]=[C:15]([C:20]1([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH2:22][CH2:21]1)[N:14]=2)[C:5](O)=[O:6].[CH2:29]([CH2:31][NH2:32])[OH:30]>>[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[C:11]1[S:12][C:13]2[C:18]([N:19]=1)=[CH:17][CH:16]=[C:15]([C:20]1([C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH2:22][CH2:21]1)[N:14]=2)[C:5]([NH:32][CH2:31][CH2:29][OH:30])=[O:6]Participants
3
Procedure
The title compound was synthesized using the procedure described in Example 105 above, with 3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzoic acid (97 mg, 0.248 mmol) and ethanolamine (18 μl, 0.298 mmol). MS (ESI) m/z: Calculated: 433.1; Observed: 434.1 (M++1).
Sources & evidence
- ORD record
- ord-59ef8b8c8b49491bab66f91a977f675d
- Source dataset
- uspto-grants-2010_11
- Patent number
- US07842685B2
Reaction notes
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