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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1177626Generated: November 4, 2026

3-azetidinecarboxylic Acid → 1-((3-Fluoro-4-(5-(1-phenylcyclopropyl)[1,3]thiazolo[5,4-b]pyridin-2-yl)phenyl)carbonyl)-3-azetidinecarboxylic acid

https://huagongshe.com/reaction/1177626

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-azetidinecarboxylic AcidHCID 93192—
Reactant3-Fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzoic acidHCID 57394406—
Product1-((3-Fluoro-4-(5-(1-phenylcyclopropyl)[1,3]thiazolo[5,4-b]pyridin-2-yl)phenyl)carbonyl)-3-azetidinecarboxylic acidHCID 59174864—

Reaction Steps

The title compound was synthesized using the procedure described in Example 105 above, with 3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzoic acid (104 mg, 0.266 mmol) and azetidine-3-carboxylic acid (32 mg, 0.320 mmol). MS (ESI) m/z: Calculated: 473.1; Observed: 474.1 (M++1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07842685B2
Source datasetuspto-grants-2010_11
ORD IDord-09396ce57cf0438dbadac7623bb858a9
Source noteuspto-grants-2010_11