Cyclopropylamine → HCID 59174839, compound

HRID 1177627Notes

Reaction equation

HRID 1177627 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[C:11]1[S:12][C:13]2[C:18]([N:19]=1)=[CH:17][CH:16]=[C:15]([C:20]1([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH2:22][CH2:21]1)[N:14]=2)[C:5](O)=[O:6].[CH:29]1([NH2:32])[CH2:31][CH2:30]1>>[CH:29]1([NH:32][C:5](=[O:6])[C:4]2[CH:8]=[CH:9][C:10]([C:11]3[S:12][C:13]4[C:18]([N:19]=3)=[CH:17][CH:16]=[C:15]([C:20]3([C:23]5[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=5)[CH2:21][CH2:22]3)[N:14]=4)=[C:2]([F:1])[CH:3]=2)[CH2:31][CH2:30]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 573944063-Fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzoic acid

Product 1

HCID 59174839HCID 59174839, compound

Procedure

The title compound was synthesized using the procedure described in Example 105 above, with 3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzoic acid (93 mg, 0.238 mmol) and cyclopropanamine (20 μl, 0.286 mmol). MS (ESI) m/z: Calculated: 429.1; Observed: 430.1 (M++1).

Sources & evidence

ORD record
ord-10c3f73e05fb4afba8d5a34494f9563a
Source dataset
uspto-grants-2010_11
Patent number
US07842685B2

Reaction notes

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