3-Amino-3-methylbutanoic acid → HCID 59174858, compound

HRID 1177629Notes

Reaction equation

HRID 1177629 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[C:11]1[S:12][C:13]2[C:18]([N:19]=1)=[CH:17][CH:16]=[C:15]([C:20]1([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH2:22][CH2:21]1)[N:14]=2)[C:5]([OH:7])=O.[NH2:29][C:30]([CH3:36])([CH3:35])[CH2:31][C:32]([OH:34])=[O:33]>>[F:1][C:2]1[CH:3]=[C:4]([C:5]([NH:29][C:30]([CH3:36])([CH3:35])[CH2:31][C:32]([OH:34])=[O:33])=[O:7])[CH:8]=[CH:9][C:10]=1[C:11]1[S:12][C:13]2[C:18]([N:19]=1)=[CH:17][CH:16]=[C:15]([C:20]1([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH2:22][CH2:21]1)[N:14]=2

Participants

3

Reactant 2

HCID 27609333-Amino-3-methylbutanoic acidHCID 573944063-Fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzoic acid

Product 1

HCID 59174858HCID 59174858, compound

Procedure

The title compound was synthesized using the procedure described in Example 105 above, with 3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzoic acid (100 mg, 0.256 mmol) and 3-amino-3-methylbutanoic acid (36 mg, 0.307 mmol). MS (ESI) m/z: Calculated: 489.2; Observed: 490.1 (M++1).

Sources & evidence

ORD record
ord-bc2de6a945b44161afe3c308092b38b8
Source dataset
uspto-grants-2010_11
Patent number
US07842685B2

Reaction notes

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