Trifluoroacetic acid → HCID 59174859, compound

Participants

Reaction Steps

A solution of tert-butyl 1-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)cyclopropyl(methyl)carbamate (0.03 g, 0.058 mmol) in chloroform (0.5 mL) was added trifluoroacetic acid (0.5 mL, 6.5 mmol) and stirred at room temperature for 2 h. The reaction mixture was concentrated in vacuo, and the resulting crude product was purified via reverse phase preparative HPLC to afford ′1-(3-fluoro-4-(5-(1-phenyl-cyclopropyl)[1,3]thiazolo[5,4-b]pyridin-2-yl)phenyl)-N-methylcyclopropanamine as a white amorphous solid. MS (ESI) m/z: Calculated: 415.5; Observed: 416.1 (M++1).

Provenance & Evidence