Lithium hydroxide, monohydrate → 4-((3-Fluoro-4-(5-(1-phenylcyclopropyl)[1,3]thiazolo[5,4-b]pyridin-2-yl)phenyl)amino)-4-oxobutanoic acid

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Reaction Steps

To methyl 4-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)-phenylamino)-4-oxobutanoate (123 mg, 0.259 mmol) was added THF/water (4:1) (2.587 m, 0.259 mmol) and lithium hydroxide hydrate (33 mg, 0.776 mmol) before it was stirred at ambient T for 30 min. The reaction mixture was concentrated, triturated with water, filtered, washed with water, and dried in a vacuum oven to give the title compound. MS (ESI) m/z: Calculated: 461.1; Observed: 462.0 (M++1).

Provenance & Evidence