HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-bromobutyrate → 1-(3-Fluoro-4-(5-(1-phenylcyclopropyl)[1,3]thiazolo[5,4-b]pyridin-2-yl)phenyl)-2-pyrrolidinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-bromobutyrate | HCID 76300 | — |
| Reactant | 3-Fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzenamine | HCID 57403052 | — |
| Product | 1-(3-Fluoro-4-(5-(1-phenylcyclopropyl)[1,3]thiazolo[5,4-b]pyridin-2-yl)phenyl)-2-pyrrolidinone | HCID 59174902 | — |
Reaction Steps
3-Fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzenamine (110 mg, 0.304 mmol) was dissolved in ethyl 4-bromobutanoate (59 mg, 0.304 mmol) before it was placed in the microwave for 60 min at 140° C. The title compound was obtained after flash chromatography. MS (ESI) m/z: Calculated: 429.1; Observed: 430.1 (M++1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07842685B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-42bc22b3b49a4a5fa5aa4de3a2b1a162 |
| Source note | uspto-grants-2010_11 |