Tetrahydrofuran → HCID 59174865, compound

Participants

Reaction Steps

(2S)-2-Acetoxy-4-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenylamino)-4-oxobutanoic acid (7.0 mg, 13 μmol) was dissolved in THF (135 μl, 13 μmol) before 0.1 N sodium hydroxide (404 μl, 40 μmol) was added and stirred at ambient temperature for 24 h. The reaction mixture was concentrated to give (2S)-4-((3-fluoro-4-(5-(1-phenylcyclopropyl)[1,3]thiazolo[5,4-b]pyridin-2-yl)phenyl)amino)-2-hydroxy-4-oxobutanoic acid after preparative LC purification. MS (ESI) m/z: Calculated: 476.1; Observed: 477.7 (M++H).

Provenance & Evidence