Sodium Hydroxide → HCID 59174855, compound

Participants

Reaction Steps

(3S)-3-Acetoxy-4-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenylamino)-4-oxobutanoic acid (65 mg, 0.125 mmol) was dissolved in THF (1.3 mL) before 0.1 N sodium hydroxide (3.75 ml, 0.375 mmol) was added and stirred at ambient temperature for 24 h; the reaction had not gone to completion, so more NaOH was added and stirred for another 4 h. The reaction mixture was concentrated to remove the THF, acidified with 2 N HCl to crash out the product, filtered, washed with water, and dried in a vacuum oven to give the title compound. MS (ESI) m/z: Calculated: 477.1; Observed: 477.7 (M++H).

Provenance & Evidence