1H-Indole-5-Carboxylic Acid → HCID 178521860, compound

Participants

Reaction Steps

A mixture of 3-amino-6-(1-phenylcyclopropyl)pyridine-2(1H)-thione (750 mg, 3.10 mmol), 1H-indole-5-carboxylic acid (499 mg, 3.10 mmol), 1H-benzo[d][1,2,3]triazol-1-ol hydrate (474 mg, 3.10 mmol), and N1-((ethylimino)methylene)-N3,N3-dimethylpropane-1,3-diamine hydrochloride (593 mg, 3.10 mmol) in DMF (3.1 mL) was stirred at ambient temperature for 16 h. The reaction mixture was diluted with 100 mL of EtOAc, added to a separatory funnel, partitioned with water, washed 2 times with 50 mL of water, separated, dried over sodium sulfate, and concentrated via rotovap to give N-(2-mercapto-6-(1-phenylcyclopropyl)pyridin-3-yl)-1H-indole-5-carboxamide. MS (ESI) m/z: Calculated: 385.1; Observed: 386.4 (M++H).

Provenance & Evidence