Ethyl Acrylate → HCID 68636008, compound

Participants

Reaction Steps

To 2-(1H-indol-5-yl)-5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine (90 mg, 0.245 mmol) was added acetonitrile (2.4 mL), ethylacrylate (80 μl, 735 μmol), and cesium carbonate (160 mg, 0.490 mmol) before it was stirred at ambient temp. for 3 h; the reaction mixture was quenched with 2 N HCl, concentrated, and was diluted with 75 mL of EtOAc, added to a separatory funnel, partitioned with water, washed 1 time with 50 mL of water, separated, dried over sodium sulfate, and concentrated via rotovap to give ethyl 3-(5-(5-(1-phenylcyclopropyl)[1,3]thiazolo[5,4-b]pyridin-2-yl)-1H-indol-1-yl)propanoate.

Provenance & Evidence