Lithium hydroxide, monohydrate → HCID 59174848, compound

Participants

Reaction Steps

Methyl 4-(5-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)-1H-indol-1-yl)butanoate (63 mg, 0.135 mmol) was dissolved in THF (1.3 mL) before lithium hydroxide, monohydrate (11 mg, 0.269 mmol) was added and stirred at ambient temperature for 3 h. The reaction mixture was concentrated, acidified with 2 N HCl, filtered, washed with water, and dried in a vacuum oven to give the title compound. MS (ESI) m/z: Calculated: 453.2; Observed: 453.8 (M++H).

Provenance & Evidence