Water → HCID 57396172, compound

Participants

Reaction Steps

Ethyl 2-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)-benzylamino)acetate (80 mg, 0.173 mmol) was dissolved in THF (1.4 mL) and water (347 μL) before lithium hydroxide monohydrate (21.82 mg, 0.520 mmol) was added and stirred at ambient temperature for 16 h. The reaction mixture was concentrated, acidified to pH 7 with 1 N HCl, filtered, and washed with water, DMSO, then water, and dried in a vacuum oven to give the title compound. MS (ESI) m/z: Calculated: 433.1; Observed: 433.8 (M++H).

Provenance & Evidence