Acetic Acid → HCID 67111881, compound

Participants

Reaction Conditions

Reaction Steps

To 3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzaldehyde (1.42 g, 3.79 mmol) was added acetic acid (12.6 mL), nitromethane (1.44 mL, 26.5 mmol), and ammonium acetate (0.731 g, 9.48 mmol) before it was stirred at 100° C. for 4 h. The reaction mixture was cooled to ambient temperature. The product crashed out with water, and was filtered, washed with water, and dried in a vacuum oven to give 2-(2-fluoro-4-(2-nitrovinyl)phenyl)-5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine. MS (ESI) m/z: Calculated: 417.1; Observed: 418.4 (M++H).

Provenance & Evidence