Methanol → HCID 57397896, compound

Participants

Reaction Conditions

Reaction Steps

To 2-(2-fluoro-4-(2-nitrovinyl)phenyl)-5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine (0.788 g, 1.89 mmol) was added THF (9.44 mL), methanol (9.44 mL), water (9.44 mL), and acetic acid (9.44 mL) before zinc (0.987 g, 15.1 mmol) was added. The reaction mixture was heated to 65° C. for 18 h. The reaction mixture was concentrated, neutralized with aq NaHCO3, and extracted with DCM. The organic layer was concentrated, filtered, washed with water, and dried in a vacuum oven to give the title compound after purification via preparatory LC. MS (ESI) m/z: Calculated: 389.1; Observed: 380.1 (M++H).

Provenance & Evidence