HRID1177716

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C[Si](C)(C)CCS(=O)(=O)n1ncc2cc(C[C@@H](NC(=O)N3CCC(N4Cc5ccccc5NC4=O)CC3)C(=O)O)ccc21

HCID58864337

未命名化合物

HCID68706663

未命名化合物

PRODUCTS

生成物

结构：O=C(O)[C@@H](Cc1ccc2[nH]c(=O)oc2c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1

HCID58864456

未命名化合物

PROCEDURE

实验过程

Prepared as described above for (R)-2-{[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidine-1-carbonyl]-amino}-3-[1-(2-trimethylsilanyl-ethanesulfonyl)-1H-indazol-5-yl]-propionic acid. The hydrolysis conditions (lithium hydroxide/methanol-tetrahydrofuran-water (1:1:1) at −15° C. overnight were used. The title compound was obtained as a white solid (95%). Mass spec.: 480.30 (MH)+.

WORKUP

后处理

customPrepared