反应详情

A flask containing a solution of 3-(1-benzylpiperidin-4-yl)-8-fluoroquinazoline-2,4(1H,3H)-dione (75.0 mg, 0.21 mmol) and palladium on charcoal (8.00 mg, 0.035 equiv) in methanol (3.00 mL) was flushed first with nitrogen, then hydrogen. The reaction was stirred under an atmosphere of hydrogen overnight. The reaction was flushed with nitrogen, filtered through celite, and concentrated to give 53 mg (95%) as a white solid which was used without purification. Mass spec.: 264.25 (MH)+.

1. customwas flushed first with nitrogen
2. customThe reaction was flushed with nitrogen
3. filtrationfiltered through celite
4. concentrationconcentrated
5. customto give 53 mg (95%) as a white solid which
6. customwas used without purification