Trifluoroacetic acid → HCID 57855674, compound

Participants

Reaction Steps

DIPEA (0.084 mL, 0.49 mmol) was added dropwise to 4-(4-benzyloxy-phenoxy)-benzoic acid (62 mg, 0.20 mmol) in DMF (4 mL). EDCI (78 mg, 0.41 mmol) and HOBT (26 mg, 0.20 mmol) were added consecutively and, after 10 mins, 2-amino-1-[4-(2-trifluoromethyl-benzoyl)-piperazin-1-yl]-ethanone in its TFA salt form (70 mg, 0.16 mmol) was added. The resulting mixture was stirred at room temperature overnight. Water was added and the resulting solid was isolated by filtration to afford 80 mg (80% yield) of 4-(4-benzyloxy-phenoxy)-N-{2-oxo-2-[4-(2-trifluoromethyl-benzoyl)-piperazin-1-yl]-ethyl}-benzamide.

Provenance & Evidence