Ammonium formate → 1-[2-(Trifluoromethyl)benzoyl]piperazine

Participants

Reaction Conditions

Reaction Steps

Ammonium formate (15.5 g, 247.126 mmol) was added to (4-benzyl-piperazin-1-yl)-(2-trifluoromethyl-phenyl)-methanone (8.6 g, 24.71 mmol) in MeOH (40 mL). Pd/C (1.8 g in 2 mL water) was then added and the resulting mixture was heated to reflux at 75° C. for 4 hours. The reaction mixture was then filtered through a bed of celite bed and the methanol was removed. EtOAc and water were then added to the residue and the organic layer was extracted, washed with 10% NaOH solution, brine, dried over sodium sulphate, and concentrated to afford 5.5 g (86% yield) of piperazin-1-yl-(2-trifluoromethyl-phenyl)-methanone.

Provenance & Evidence