HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Alcohol → 4-Piperidinecarboxylic acid, phenylmethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Alcohol | HCID 244 | — |
| Reactant | 4-Piperidinecarboxylic acid | HCID 3773 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Product | 4-Piperidinecarboxylic acid, phenylmethyl ester | HCID 11413336 | 97.25% |
Reaction Steps
Thionyl chloride (5.42 g, 46 mmol) was added to a cold (0-4° C.) stirred solution piperidine-4-carboxylic acid (5 g, 38.7 mmol) in benzyl alcohol (150 mL) and stirring was continued overnight. Benzyl alcohol was removed by stirring with hexane, ether and decanting the solvent, dried to afford 8.26 g (97.25% yield) of piperidine-4-carboxylic acid benzyl ester. LCMS Purity: 94.8%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07842696B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-9e2ad0e6c14d4ec79ca2c63acf10558a |
| Source note | uspto-grants-2010_11 |