Trifluoroacetic acid → 2-amino-1-[4-(2-trifluoromethyl-benzoyl)-piperazin-1-yl]-ethanone TFA salt

HRID 1177946Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1177946
[C:1]([OH:7])([C:3]([F:6])([F:5])[F:4])=[O:2].C(OC(=O)[NH:14][CH2:15][C:16](=[O:35])[N:17]1[CH2:22][CH2:21][N:20]([C:23](=[O:34])[C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[C:30]([F:33])([F:32])[F:31])[CH2:19][CH2:18]1)(C)(C)C>C(Cl)Cl>[OH:7][C:1]([C:3]([F:6])([F:5])[F:4])=[O:2].[NH2:14][CH2:15][C:16]([N:17]1[CH2:18][CH2:19][N:20]([C:23](=[O:34])[C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[C:30]([F:33])([F:31])[F:32])[CH2:21][CH2:22]1)=[O:35]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 59559599{2-Oxo-2-[4-(2-trifluoromethyl-benzoyl)-piperazin-1-yl]-ethyl}-carbamic acid tert-butyl ester

Produkt 1

HCID 866340882-amino-1-[4-(2-trifluoromethyl-benzoyl)-piperazin-1-yl]-ethanone TFA saltAusbeute 84,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

TFA (6 mL) was added to a chilled (0° C.) solution of {2-Oxo-2-[4-(2-trifluoromethyl-benzoyl)-piperazin-1-yl]-ethyl}-carbamic acid tert-butyl ester (3.0 g, 7.7 mmol) in DCM (30 mL) and stirring was maintained at this temperature for 2 hrs. The solvent was removed under reduced pressure and the resulting residue was washed with ether to afford 2.8 g (84.8% yield) of 2-amino-1-[4-(2-trifluoromethyl-benzoyl)-piperazin-1-yl]-ethanone TFA salt.

Aufarbeitung

  1. temperaturewas maintained at this temperature for 2 hrs
  2. customThe solvent was removed under reduced pressure
  3. washthe resulting residue was washed with ether

Quellen und Nachweise

ORD-Eintrag
ord-01f43863f9994b349e48e277d3e1a4bf
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07842696B2

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