反应详情

TFA (6 mL) was added to a chilled (0° C.) solution of {2-Oxo-2-[4-(2-trifluoromethyl-benzoyl)-piperazin-1-yl]-ethyl}-carbamic acid tert-butyl ester (3.0 g, 7.7 mmol) in DCM (30 mL) and stirring was maintained at this temperature for 2 hrs. The solvent was removed under reduced pressure and the resulting residue was washed with ether to afford 2.8 g (84.8% yield) of 2-amino-1-[4-(2-trifluoromethyl-benzoyl)-piperazin-1-yl]-ethanone TFA salt.

1. temperaturewas maintained at this temperature for 2 hrs
2. customThe solvent was removed under reduced pressure
3. washthe resulting residue was washed with ether