HCID 25164321, compound → HCID 25164723, compound

Participants

Reaction Steps

4-Nitro-N-{2-oxo-2-[4-(2-trifluoromethyl-benzoyl)-piperazin-1-yl]-ethyl}-benzamide (57 mg, 0.12 mmol) was dissolved in Methanol (1 mL). 10% Pd/C (10 mg) was added and the resulting mixture stirred for 4 hrs. The mixture was filtered over celite bed, and the filtrate was concentrated to afford 26 mg (49.1% yield) of 4-amino-N-{2-oxo-2-[4-(2-trifluoromethyl-benzoyl)-piperazin-1-yl]-ethyl}-benzamide. LCMS Purity: 97.4%, 1H NMR (CDCl3): δ 7.8-7.5 (m, 5H), 7.4-7.3 (d, 1H), 7.1-7.0 (s, 1H), 6.7-6.6 (d, 2H), 4.3-4.1 (m, 2H), 4.0 (bs, 3H), 3.8-3.5 (m, 5H), 3.4 (t, 1H), 3.2 (m, 2H).

Provenance & Evidence