HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1177979Generated: October 31, 2026
4-Hydroxybenzaldehyde → 6-(4-Formylphenoxy)nicotinonitrile
https://huagongshe.com/reaction/1177979
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Hydroxybenzaldehyde | HCID 126 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 6-Chloro-3-pyridinecarbonitrile | HCID 5152094 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-(4-Formylphenoxy)nicotinonitrile | HCID 47150216 | 84.3% |
Reaction Steps
K2CO3 (450 mg, 3.27 mmol) and 6-chloronicotinonitrile (270 mg, 1.97 mmol) were added to 4-hydroxy-benzaldehyde (200 mg, 1.64 mmol) in DMF (2 mL) and the resulting mixture was heated to 70° C. for 3 hrs. The reaction mixture was then diluted with water and the resulting was filtered and dried to afford 310 mg (79.1% yield) of 6-(4-formyl-phenoxy)nicotinonitrile. LCMS Purity: 97.3%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07842696B2 |
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| Source dataset | uspto-grants-2010_11 |
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| ORD ID | ord-b69b6ca2d177493ab0893f30a84bef48 |
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| Source note | uspto-grants-2010_11 |
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