HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phthalic Anhydride → 2-(4-Boc-piperazine-1-carbonyl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phthalic Anhydride | HCID 6811 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-(4-Boc-piperazine-1-carbonyl)benzoic acid | HCID 2796203 | — |
Reaction Steps
A mixture of piperazine-1-carboxylic acid tert-butyl ester (167 mg, 0.90 mmol) and pthalic anhydride (160 mg, 1.08 mmol) in toluene (20 mL) were heated to reflux for 2 hours. The reaction mixture was concentrated under reduced pressure to afford 4-(2-carboxy-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07842696B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-b8baac0ff53344cc9e13c8564dff677e |
| Source note | uspto-grants-2010_11 |