Trifluoroacetic acid → 2-(Piperazine-1-carbonyl)-benzoic acid methyl ester

Participants

Reaction Steps

TFA (1.2 mL) was added to a stirred solution of 4-(2-Methoxycarbonyl-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester (200 mg, 0.58 mmol) in DCM (5 mL) at 0° C. The resulting mixture was stirred at the same temperature for 2 hours. DIPEA (1.5 mL) was added to the cold reaction mixture and the mixture was concentrated under reduced pressure to afford 2-(piperazine-1-carbonyl)-benzoic acid methyl ester.

Provenance & Evidence