HCID 66953970, compound → HCID 59559570, compound

Participants

Reaction Steps

10% Pd/c (40 mg) was added to a stirred solution of 5-(3-benzyloxy-phenyl)-isoxazole-3-carboxylic acid {2-oxo-2-[4-(2-trifluoromethyl-benzoyl)-piperazin-1-yl]-ethyl}-amide (74 mg, 0.12 mmol) (prepared by the method as described above) in MeOH (30 mL) and stirred under hydrogen atmosphere. The reaction mixture was then stirred for 6 hrs. The mixture was filtered over a bed of celite. The celite was washed with MeOH and the filtrate was concentrated under reduced pressure to afford 26 mg (41.9% yield) of 5-(3-hydroxy-phenyl)-isoxazole-3-carboxylic acid {2-oxo-2-[4-(2-trifluoromethyl-benzoyl)-piperazin-1-yl]-ethyl}-amide. LCMS Purity: 99.07%. 1H NMR (CD3OD): δ 7.64 (m, 4H), 7.5 (d, 1H), 7.32 (m, 1H), 7.24 (s, 1H), 6.98 (m, 2H), 4.26 (m, 2H), 3.7 (m, 4H), 3.5 (m, 2H), 3.38 (m, 1H), 3.24 (m, 1H).

Provenance & Evidence