Hydrochloric Acid → HCID 178523546, compound

Participants

Reaction Conditions

Reaction Steps

HOBt (24 mg, 0.18 mmol) and DIPEA (74 mg, 0.57 mmol) were added to a stirred solution of 5-phenyl-1H-pyrazole-3-carboxylic acid; hydrochloride (32 mg, 0.14 mmol) in DMF (1.0 mL). The mixture was then cooled to 10° C. and EDCI.HCl (34 mg, 0.18 mmol), followed by 2-amino-1-[4-(2,5-dichloro-benzoyl)-piperazin-1-yl]-ethanone hydrochloride (50 mg, 0.14 mmol) were added. The reaction mixture was then stirred at room temperature overnight. Water was added, and the resulting precipitate was isolated by filtration and dried under reduced pressure to afford 5-phenyl-1H-pyrazole-3-carboxylic acid {2-[4-(2,5-dichloro-benzoyl)-piperazin-1-yl]-2-oxo-ethyl}-amide as a solid in 89.47% Yield. LC-MS purity: 92.226%. 1H-NMR (DMSO): δ 8.6 (s, 1H), 8.1 (t, 1H), 7.8 (m, 2H), 7.6 (m, 3H), 7.45 (m, 4H), 7.1 (s, 1H), 3.9 (m, 2H), 3.4 (m, 6H), 3.2 (m, 2H).

Provenance & Evidence